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Introducción. El índice metabólico pediátrico (IMP) constituye un índice específico para cada sexo y edad, propuesto para predecir alteraciones cardiometabólicas en esa población. El objetivo del presente estudio fue evaluar el IMP en adolescentes según la agrupación de factores de riesgo cardiovascular (FRCV) y su relación con indicadores de adiposidad, dislipidemia, estrés oxidativo, inflamación, resistencia a la insulina e hipertensión en adolescentes. Metodología. El estudio fue descriptivo, correlacional y transversal en 80 adolescentes. Se determinó la glicemia, perfil lipídico, insulina, PCR ultrasensible, IL-6, TNF-α, 8-isoprostano y LDL oxidada, y se calculó el índice HOMA-IR. Se midió el peso, talla y circunferencia de cintura, y se determinó el índice de masa corporal, el de conicidad, la relación cintura/talla y luego se determinó el IMP. También, se determinó la presión arterial, la actividad física y el hábito tabáquico. Resultados. Quienes presentaron tres o más FRCV, mostraron valores de IMP superiores a los que presentaron menos factores de riesgo (p<0,001). Además, el IMP se correlacionó con indicadores de adiposidad, presión arterial, componentes del perfil lipídico, marcadores de estrés oxidativo y el HOMA-IR. Conclusión. El IMP se incrementó a medida que lo hizo la agrupación de FRCV, y el mismo se relacionó con la mayoría de los indicadores estudiados, a excepción de los marcadores de inflamación y los niveles de glucosa. Adicionalmente, el IMP resultó ser un indicador de fácil determinación y aplicación, el cual puede corroborar o complementar los hallazgos clínicos que pudieran detectarse mediante el uso de indicadores antropométricos de uso cotidiano en la práctica médica
Introduction. The pediatric metabolic index (PMI) is a specific index according to sex and age to predict cardiometabolic alterations in this population. The objective of this study was to assess the PMI in adolescents according to grouped cardiovascular risk factors (CVRF) and its relationship with indicators of adiposity, dyslipidemia, oxidative stress, inflammation, insulin resistance and hypertension in adolescents. Methodology. The study was descriptive, correlational and cross-sectional in 80 adolescents. Glycemia, lipid profile, insulin, ultrasensitive PCR, IL-6, TNF-α, 8-isoprostane and oxidized LDL were determined, and the HOMA-IR index was calculated. The weight, height and waist circumference were measured, and the body mass index, conicity index, waist/height ratio were determined and then the PMI was calculated. Blood pressure, physical activity and smoking levels were also determined. Results. Those who presented three or more CVRF showed higher PMI values than those who presented less risk factors (p<0.001). In addition, the PMI correlated with indicators of adiposity, blood pressure, lipid profile components, oxidative stress markers and HOMA-IR. Conclusion. The PMI increased as the group of CVRF did, and it was related to the majority of the indicators studied, except for the markers of inflammation and glucose levels. Additionally, the PMI turned out to be an indicator of easy determination and application, which can corroborate or complement the clinical findings that could be detected through the use of anthropometric indicators of daily use in medical practice.
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Humans , Basal Metabolism , Pediatrics , Cardiovascular Diseases , Body Mass Index , Risk Factors , Adolescent , Arterial PressureABSTRACT
Objective To study correlation between serum 25 (OH) d level and metabolic indexes in elderly patients with diabetes mellitus. Methods In this prospective study, 315 elderly patients with diabetes who were diagnosed and treated in our hospital from January 2018 to June 2020 were selected as the research objects, and 100 healthy volunteers in the same period were selected as the control group. The blood lipid, fasting blood glucose (FPG), fasting insulin (fins), glycosylated hemoglobin (HbA1c) and insulin resistance (HOMA) of the two groups were analyzed- The levels of FPG, fins, GHbA1c, HOMA-IR and homa-is in patients with 25 (OH) D deficiency of different severity were compared, and the correlation between serum 25 (OH) d level and metabolic indexes was studied. Results The serum 25 (OH) d level of the observation group was significantly lower than that of the control group (t = 6.080, P = 0.000); the FPG (t = 14.708, P = 0.000), GHbA1c (t = 7.165, P = 0.000), HOMA-IR (t = 8.880, P = 0.000) of the observation group were significantly higher than those of the control group, homa-is (t = 120.847, P = 0.000), fins (t = 120.847, P = 0.000)= The levels of FPG (F = 12.334, P = 0.000), fins (F = 11.897, P = 0.000), GHbA1c (F = 10.090, P = 0.000), HOMA-IR (F = 11.232, P = 0.000) and homa-is (F = 9.009, P = 0.000) were not significantly different between the two groups (P < 0.05) FPG, GHbA1c, HOMA-IR of patients from high to low were deficiency group, deficiency group and sufficiency group, fins, homa-is levels from high to low were sufficiency group, deficiency group and deficiency group; through correlation analysis, serum 25 (OH) d levels of patients were negatively correlated with FPG, GHbA1c, HOMA-IR, and positively correlated with fins, homa-is. Conclusion The level of serum 25 (OH) d in elderly patients with diabetes is significantly correlated with metabolic indexes, which can become one of the important evaluation indexes of treatment effect in the future.
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Objective: The objective of the present study was to assess the nutritional status of adolescent girls and to investigate its association with socio-economic status, eating and physical activity pattern. Methods: A cross-sectional survey was conducted among adolescent girls (15 and 19 years) and stratified random sampling technique was done in 4 schools of Arar city, KSA. Subjects were asked to fill pre-tested questionnaire about socio-economic status, dietary and physical activity pattern and their height and weight were measured and BMI (kg/m2) was calculated. SPSS version 22 (2017) was used in entering, managing survey data and to analyze the obtained data. A p-value<0.05 was considered statistically significant for individual variables. Results: The final study sample consisted of 322 adolescent girls (response rate of 90.96%), with a mean age of 17.14 ± 1.15 years. More than one-fifth of the study population was overweight and obese, moreover, about three-fifth of the study population were of normal weight, while 19.2% were underweight. A significant relationship was observed between nutritional status with the mother’s occupation and education, family size, and a number of meals taken per day. Conclusion: Adolescent’s populations face two contrasting nutrition situations, under and over nutrition. This study will help in generating imperative data and recommendations for managing nutrition-related problems in adolescent girls in Saudi Arabia.
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El objetivo del presente estudio fue evaluar la asociación entre el índice metabólico, una medida indirecta de resistencia a la insulina, y la hipercolesterolemia en población indígena maya con diabetes tipo 2 (DT2). Se incluyeron un total de 77 pacientes indígenas mayas con diagnóstico previo de DT2. Las variables bioquímicas se analizaron por métodos fotométricos estandarizados y se calculó el índice metabólico (GB x TG/HDL-C2). Se encontró en la muestra total una correlación entre el índice metabólico y los niveles de: glucosa basal (GB) (r=0,333, p=0,001), A1c (r=0,331, p=0,003), CT (r=0,255, p=0,026), TG (r=0,762, p=1,29x10-15), HDL-C (r= -0,735, p=4,2x10-14); mientras que no existió correlación con las concentraciones de LDL-C (r=0,120, p=0,300). La asociación entre el índice metabólico e hipercolesterolemia (B=1,590, p=0,041, Exp(B)=4,901 e I.C=1,066-22,544) fue independiente de la edad, género, IMC, tiempo de evolución de DT2 y de los niveles de A1c. El trabajo presenta evidencia de la asociación entre el índice metabólico y la hipercolesterolemia, y propone el potencial uso del índice metabólico como medida indirecta de riesgo aterogénico en población indígena maya con DT2.
It is already known that combination of insulin resistance (IR) and compensatory hyperinsulinemia increases the risk of hypertension, and atherogenic dyslipidemia. These changes increase the risk of cardiovascular disease. With that in mind, the aim of the present study was to evaluate the association between elevated metabolic index, an indirect measure of insulin resistance, and hypercholesterolemia in an indigenous Mayan population with type 2 diabetes (T2D). A total of 77 indigenous Mayan patients with a previous diagnosis of T2D were included. Biochemical variables were measured by standardized photometric methods and the metabolic index (GB x TG/HDL-C2) was calculated. A correlation between the metabolic index and the levels of GB (r=0.333, p=0.001), A1c (r=0.331, p=0.003), CT (r=0.255, p=0.026), TG (r=0.762, p=1.29x10-15), HDL-C (r=-0.735, p=4.2x10-14) was found; while there was no correlation with LDL-C concentrations (r=0.120, p=0.300). The association between the metabolic index and hypercholesterolemia (B=1.590, p=0.041, Exp(B)=4.901 and I.C=1.066-22.544) was independent of A1c levels, age, gender, BMI and evolution time of DT2. The study presents evidence of the association between the metabolic index and hypercholesterolemia, and proposes the potential use of the metabolic index as an indirect measure of atherogenic risk in an indigenous Mayan population with T2D.
O objetivo do presente estudo foi avaliar a associação entre a taxa metabólica, uma medida indireta de resistência à insulina e a hipercolesterolemia na população indígena maia com diabetes tipo 2 (DT2). Foram incluídos 77 pacientes indígenas maias com diagnóstico prévio de DT2. As variáveis bioquímicas foram medidas através de métodos fotométricos padronizados e foi calculado o índice metabólico (GB x TG/HDL-C2). Uma correlação entre o índice metabólico e os níveis de glicose basal (GB) (r=0,333, p=0,001), A1c (r=0,331, p=0,003), CT (r=0,255, p=0,026), TG (r=0,762, p=1,29x10-15), HDL-C (r=-0,735, p=4,2x10-14) foi encontrada na amostra total; enquanto que não houve correlação com as concentrações de LDL-C (r=0,120, p=0,300). A associação entre o índice metabólico e a hipercolesterolemia (B=1,590, p=0,041, Exp(B)=4,901 e I.C=1,066-22,544) foi independente da idade, sexo, IMC, tempo de evolução de DT2 e dos níveis de A1c. O trabalho apresenta evidência da associação entre o índice metabólico e a hipercolesterolemia, e propõe o potencial uso do índice metabólico como medida indireta do risco aterogênico na população indígena maia com DT2.
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Humans , Population , Basal Metabolism , Diabetes Mellitus, Type 2 , Hypercholesterolemia , Association , Population Groups , Gender Identity , Cholesterol, HDLABSTRACT
Objective To analysis the metabolic index among diabetic patients in community in summer and winter,and to provide evidence for disease management.Methods During June and December,119 diabetic patients were seleted from communities living for more than a year by the method of stratified cluster sampling.The metabolic indexes were compared usingpaired t test ,and the rate of biochemical indicators were analyzed by McNemar 's test between two seasons .Results The values of HbA1c,GLU and HDL -C were higher in winter than in summer (P <0.01).The mean values of TC in summer and winter were the same.The detection values of triglyceride and low density lipoprotein were lower in winter than in summer,but the difference was not statistically significant (P >0.05 ).The control rate of HbA1c was 56.36% in summer,and the control rate was 44.54% in winter,the difference was statistically significant (P <0.05).In summer, the control rate was 59.66%,higher than 45.38% in winter,and the difference was statistically significant (P <0.05). The control rate of blood pressure was better than that in winter,while triglyceride and low density lipoprotein control was better than that in summer,but which was not statistically significant (P >0.05).Conclusion The metabolic index of diabetic patients in Zhoushan urban community was significantly affected by seasonal changes.Most indexes were better in summer than that in winter,which suggested that the intervention of diabetics should be enhanced in winter.
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The aim of this study was to evaluate the health risks of solid waste disposal workers and scavengers, involved in the handling and disposal of municipal wastes, especially their cardiovascular health. The study was carried out in Port Harcourt, Nigeria from 2011 to 2013. Male solid waste disposal workers and scavengers (n=100) aged between 19 and 53years who have worked from six months to 15 years in waste disposal industry, were used in this study. Twenty six percent were aged 40 years and above while 74% were aged between 19 to 39 years. These were compared with 100 male subjects of same age group (21 to 50) who were not solid waste disposal workers; they served as the control group. Their blood pressures (systolic and diastolic) were measured using a standard mercury sphygmomanometer, weight was measured using calibrated electronic scale and height was measured using a Stadiometer. Body Mass Index (BMI) was calculated by the formula (weight/height2). These were used as indices of cardiovascular disease in the volunteers. The level of malaria parasitemia was evaluated. A well-structured questionnaire was given to each volunteer in this study as a behavioral determinant. Mean systolic pressure of the solid waste disposal workers and the control group were 136±13.58 mmHg (Mean ± SD) and 117±12-04 mmHg respectively. The diastolic pressures were 88±12.73 mmHg and 71±10.71 mmHg respectively. This was significant (p<0.01) despite the fact that the solid waste disposal workers had a lower BMI value (24.25±3.19 Kg/M2) than the controls (29.46±3.75 Kg/M2). The increase in blood pressure cuts across duration of exposure, 55.84% of the solid waste disposal workers reported regular alcohol intake, while 43.27% reported current tobacco use against 20% and 7% of the control group. There was no significant difference (p>0.01) when the blood pressures of solid waste disposal workers aged 40 and above was compared with that of 19 to 39 age group. Prevalence of malaria parasitaemia was higher in the solid waste disposal workers in comparison to the controls 92% and 69% respectively.
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Objective: To study the differences between the lipid profiles of the subjects whose parents are having known non-modifiable risk factors such as obesity, hypertension (HTN), myocardial infarction and diabetes, and compare them with the lipid profiles of the subjects whose parents are not having those risk factors. Methods: A total of 402 subjects were recruited to this study. A detailed questionnaire which included information on the past medical history, height, weight, blood pressure, physical activity, smoke, alcohol, family history of coronary heart disease, HTN, diabetics and obesity. Basic demographic data and dietary habits were completed by all participants. Blood samples were obtained from all subjects after 14 h. Lipid profiles were analyzed using automated analyzer. The results were analyzed using SPSS software packages. Results: The mean body mass index of the population was well below the cut-off value of obesity (>24.5 kg/m
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<p><b>OBJECTIVE</b>To identify the bamboo VOCs (volatile organic compounds) effect on animal physiological indices, which associated with human health.</p><p><b>METHODS</b>GC/MS was used to analyze the volatile organic compounds from Moso bamboo (Phyllostachys heterocyla cv. pubescens). The effect of VOCs on environmental health was evaluated by analyzing the metabolic indices of the type 2 diabetic mouse model.</p><p><b>RESULTS</b>Spectra of VOC generated by GC/MS were blasted against an in-house MS library confirming the identification of 33 major components that were manually validated. The relative constituent compounds as a percentage of total VOCs determined were alcohols (34.63%), followed by ether (22.02%), aldehyde (15.84%), ketone (11.47%), ester (4.98%), terpenoid (4.38%), and acids (3.83%). Further experimentation established that the metabolic incidence of the disease can be improved if treated with vanillin, leaf alcohol, β-ionone and methyl salicylate. The effects of these VOCs on type 2 diabetes were evident in the blood lipid and blood glucose levels.</p><p><b>CONCLUSION</b>Our model suggests that VOCs can potentially control the metabolic indices in type 2 diabetes mice. This experiment data also provides the scientific basis for the comprehensive utilization of ornamental bamboos and some reference for other similar study of environmental plants.</p>
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Animals , Male , Mice , Bambusa , Chemistry , Blood Glucose , Metabolism , Diabetes Mellitus, Type 2 , Metabolism , Disease Models, Animal , Environmental Health , Gas Chromatography-Mass Spectrometry , Lipids , Blood , Mice, Inbred ICR , Volatile Organic Compounds , PharmacologyABSTRACT
Objective To investigate the effects of 1,25-dihydroxyvitamin D_3 on the bone metabolism of primary osteoporosis.Methods Female New Zealand white rabbits aged 8 months were ovariectomized bilaterally as models of postmenopausal osteoporosis and they were randomly divided into 4 groups: pseudo-ovariectomized group(Sham group),ovariectomized group(OVX group),calcii gluconas group(OC group),calcii gluconas and 1,25-dihydroxyvitamin D_3 group(OCR group).Both female New Zealand white rabbits aged 3 years and male New Zealand white rabbits aged 4 years were selected as models of senile osteoporosis.They were randomly divided into 3 groups:control group,calcii gluconas group(Calcium group),calcii gluconas and 1,25-dihydroxyvitamin D_3 group(CR group).Rabbits in OC group and Calcium group were given calcii gluconas and in OCR group and CR group were given calcii gluconas and 1,25-dihydroxyvitamin D_3.The bone metabolic biochemical indexes were determined among all the experimental animals after they were given drug for 8 weeks.Results After the experimental animals were given drug for 8 weeks,the serum calcium(Ca),serum phosphorus(P) and alkaline phosphatase(ALP) of OCR group were significantly higher than those of OVX group and OC group(all P